In the redesigned 6R series for 2022, the model designations were changed to match the larger model series, meaning the end part of the designation now indicates the nominal power in horsepower. There were minor changes in the exterior, and the side mirrors were green. The instrument cluster was moved to the front pillar. Power and torque figures were mostly the same as in the previous lineup. The engines of the 6-cylinder models were 6.7 liters and had one variable geometry turbocharger, except for the two largest models which had two. Additional power was now available not only for road and PTO use but also when using hydraulics.

The base transmission was a 20+20 AutoQuad Plus, featuring quick-shift automation while keeping the base gear the same. Three versions were available: 40 km/h, 50 km/h, and 40 km/h Ecoshift. An alternative was the dual-clutch DirectDrive transmission with 24+24 speeds. All models were also available with a stepless AutoPowr transmission (ZF Eccom), which was the only option for the 185, 230, and 250 models. Hydraulic output was 114 liters per minute or, for an additional charge, 155 liters per minute. The two largest models came standard with 160 liters per minute. Hydraulic blocks were available with 6 sections at the rear and 3 in the center. Power Beyond was standard.

In optional precision farming features, emphasis was placed on the user creating driving lines and fertilizing maps in advance via a cloud service and sending them to the tractor. The cab noise level was 71 dB. The cab could be ordered as either a 4-pillar or 5-pillar version, the latter offering easier access. The windshield wiper was now relocated to the bottom of the windshield, following the trend of many other manufacturers. Standard was an 8.4-inch CommandCenter 4200 display. The CommandPro control handle, introduced a couple of years earlier, was still an optional extra.

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