The MF 6600 series, which went on sale in the summer of 2013, was simply put a four-cylinder version of the 7600 series. The wheelbase was 20 cm shorter and the weight was 500 kilograms less. With the 6600 series, the last Perkins engines disappeared from the MF lineup on the Western European market. The 6600 featured 4.9-liter Agco Power engines equipped with urea injection. The Dyna-4 models had an additional 15 hp, and the Dyna-6 models had 25 hp more power. As was typical for MF, the extra power was available already from about 6 km/h (gear 2D). However, the highest power of the Dyna-6 also required power transmission through the PTO (power take-off).

The base models were simpler in a couple of details compared to the 6400 series. In addition to the 4-speed powershift, they had an open hydraulic system familiar from the 5400/5600 series, where combining the hydraulic and implement pumps produced 100 l/min output. With the Dyna-6, the hydraulics were load-sensing. Lift capacity was increased to 7,100 kilograms. Both the 4- and 6-speed powershift models had an electro-hydraulic range shift and automatic shifting for the powershift as standard. The clutch could be controlled, if desired—for example, in front loader use—also by the brake pedal. The front axle had a 100% lock. The fuel tanks, at 250 liters, were significantly larger than those on the previous 4-cylinder models. The cab was the same as in the 7600 series, with a reported noise level of 70 dB.

There were three equipment levels. The basic Essential model was available with both transmission options. Standard equipment included mechanically controlled hydraulics (3 sections), air conditioning, an air-suspension seat, and a passenger seat. In Finland, a supplementary heater and a trailer brake valve were also standard.

The Efficient model featured the Dyna-6 transmission, mechanical cab suspension, two-section electro-hydraulic valves for the hydraulics, an armrest control device, cruise control memory, and a radio with an SD card slot. In Finland, front axle suspension and folding front fenders were also standard.

The Exclusive model had a multifunction joystick integrated into the armrest. In addition, it came standard with four electro-hydraulic spool valves, semi-active cab suspension, automatic air conditioning, traction control radar, a Datatronic 4 ISOBUS terminal, and headland automation.

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